Die wichtigsten Publikationen von Prof. Dr. med. Helmut K. Seitz

Homann N, Mueller S, Schröder F, Moreira B, Teng H, Bruckner T, Haefeli W, Seitz HK (2021) Clomethiazol inhibits cytochrome P450 2E1 and improves alcoholic liver disease. Gut 71; 842-4. May 10; gutjnl-2021-324727. doi: 10.1136/gutjnl-2021-324727). 

Schwantes-An TH, Darley R, Mathurin P, Masson S, Liangpunsakul S, Mueller S, Aithal GP, Eyer F, Gleeson D, Thompson A, Muellhaupt B, Stickel F, Soyka M, Goldman, Lumeng L, Pirmohamed M, Nalpas B, Jacquet JM, Moirand R, Nahon P, Naveau S, Perney P, Botwin G, Haber PS, Seitz HK, Day CP, Foroud TM, Ann KD, Cordell HJ, Whitfield JB,  Morgan TM, Seth D, for the GenomALC Consortium (2021). Genome-wide association study and meta- analysis identifies novel risk factors for alcohol related liver cirrhosis. Hepatology 73, 1920-31. 

Seitz HK, Mueller S (2018) Alkoholische Lebererkrankung: Risikofaktoren, Diagnostik und Therapie. Verdauungskrankheiten 36:104-113 

Köhler B, Arslic-Schmitt, Pecerella T, Scherr AL, Schulze-Bergkamen H, Bruckner T, Gdynia G, Jäger D, Bartsch H, Seitz HK (2016) 
Upregulation of Mcl-1, an anti-apoptotic protein as a possible mechanism for ethanol- mediated colorectal carcinogenesis in heavy drinkers.  
Alcoholism Clin Exp Res  40: 2094-2101 

Millonig G, Bernhardt F, Wang Y, Mueller S, Homann N, Bartsch H, Seitz HK (2011) 
Ethanol-mediated carcinogenesis in the human esophagus implicates Cytochrome P-4502E1 induction and the generation of carcinogenic DNA-lesions.  
Int J Cancer 128, 533-40. 

Seitz HK, Stickel F (2009): 
Acetaldehyde, an underestimated risk factor in cancer development: role of genetics in ethanol metabolism.  
Genes Nutr. 2010; 5 (2): 121-128 

Wang Y, Millonig G, Nair J, Patsenker E, Stickel F, Mueller S, Bartsch H, Seitz HK (2009): 
Ethanol-induced cytochrome P-4502E1 causes carcinogenic etheno-DNA lesions in alcoholic l liver disease. 
Hepatology 50, 453-61. 

Seitz HK, Stickel F (2007) Molecular mechanisms in ethanol mediated carcinogenesis. Nature Cancer Rev. 7: 599-612. 

Homann N, Stickel F, König IR, Junghanns K, Benesova M, Schuppan D, Himsel S, Zuber-Jerger I, Hellerbrand C, Ludwig D, Caselmann WH, Seitz HK (2006): Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers. Int J Cancer 118: 1998-2002. 

Schlemmer HPW, Sawatzki T, Dornacher I, Sammet S, Bachert P, Hellenschmitt M, van Kaick G, Seitz HK (2005): Proton decoupled 31P MR-spectroscopy imaging of the liver: a new method for the assessment of altered hepatic phospholipid metabolism in patients with alcoholic liver disease. J Hepatol 42, 752-59. 

Visapää JP, Götte K, Benesova M, Li JJ, Homann N, Conradt C, Inoue H, Tisch M, Hörrmann K, Väkeväinen S, Salaspuro M, Seitz HK (2004): Increased risk of upper aerodigestive tract cancer in heavy drinkers with ADH 1C*1 ly allele possibly due to increased salivary acetaldehyde concentrations. Gut 53: 871-876. 

Oneta CM, Lieber CS, Li JJ, Rüttimann S, Schmid B, Lattmann J, Rosman A, Seitz HK (2002): 
Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase. 
J Hepatology 36: 47-52. 

Simanowski UA, Homann N, Knühl M, Arce L, Waldherr R, Conradt C, Bosch F, Seitz HK (2001):  
increased rectal cell proliferation following alcohol abuse.  
Gut 49: 418-22. 

Gebhardt A, Lucas D, Menez JF, Seitz HK (1997): 
Chlomethiazole inhibition of cytochrome P4502E1 as assessed by chlorzoxazone hydroxylation in humans.  
Hepatology 26: 957-961. 

Oneta CM, Simanowski UA, Martinez M, Alali Hassani A, Parés X, Homann N, Conradt C, Waldherr R, Fiehn W, Coutelle C, Seitz HK (1998): 
First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying.  
Gut 43: 612-619. 

Seitz HK, Kuhn B, v.Hodenberg E, Fiehn W, Simanowski UA (1994):  
Increased messenger RNA levels for low density lipoprotein receptor and 3-hydroxy-3- methylglutaryl-coenzyme-A-reductase in rat liver after long-term ethanol ingestion.  
Hepatology 20: 487-93. 

Simanowski UA, Suter P, Russell RM, Heller M, Waldherr R, Ward R, Peters TJ , Smith D, Seitz HK (1994):  
Enhancement of ethanol- induced rectal hyperregeneration with age in F344 rats. 
Gut 35: 1102-6.   

Simanowski UA, Suter P, Stickel F, Maier H, Waldherr R, Smith D, Russell RM, Seitz HK (1993): 
Esophageal epithelial hyperregeneration following long term alcohol consumption in rats: effects of age and salivary gland function.  
JNCI 85: 2030-2033.   

Seitz HK, Egerer G, Simanowski UA, Waldherr R, Eckey R, Agarwahl DP, Goedde WH, v.Wartburg JP (1993): 
Human gastric alcohol dehydrogenase activity: effect of age, gender and alcoholism.  
Gut 34: 1433-1437.   

Seitz HK, Simanowski UA, Garzon FT, Rideout JM, Peters TJ, Koch A, Berger MR, Einecke H, Maiwald M (1990):  
Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat.  
Gastroenterology 98: 406-413.